| MECHANISM OF ACTION OF COLCHICUM
It inhibits the chemotactic response of the polymorphonuclear leukocyte, and is therefore anti-inflammatory. Colchicum inhibits the release of lysosomal enzymes from the macrophages during phagocytosis and is anti-inflammatory. Colchcicum inhibits histamine production, demonstrating anti-allergic response. Following it's use, certain structural changes return to normal. Colchicum brings about remission of the patient's problem so that a natural healing of the disc occurs. It gets the patient "over the hump" as far as the intractable nature of the disc inflammation is concerned. The disc then "quiets down" and the patient's natural healing is allowed to finish the job, obviating the need for invasive surgery. It is believed that there is an anti-inflammatory effect that colchicum has that others do not. This is what has been called "disc shrinking action".
(1)Histochemical demonstration of nitric oxide in herniated lumbar discs. A clinical and animal model study. Hashizume H., Spine 1997 May 15;22(10):1080
(2)Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostgladin, E2, and matrix metalloproteinases, Kang JD. Spine 1997, May.
(3)Vascularization induced by annulus and its inhibition by cartilage endplate. It's role in disc absorption. Carreon LY., Spine 1997 July 1;22(13)1429-34; discussion 1446-7
(4)The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat. Kawakami M. Spine 1997 May 15;22 (10):1074-9